Potential risk factors included the total number of instances of vaginal intercourse (continuous variable), the number of new partners (0, 1, or >1), the frequency of condom use by partners (<5 percent, 5 to 49 percent, 50 to 99 percent, or 100 percent), the partner's circumcision status (circumcised, uncircumcised, or unknown), and the partner's number of previous partners (0, ?1, or unknown). The frequency of condom use was calculated by dividing the number of condoms used for vaginal intercourse by the number of instances of vaginal intercourse during the eight-month study period. If multiple new partners were reported during an eight-month period, the circumcision status and previous number of partners were summarized ( Table 1 ). The percentage of days that lacked diary entries was calculated to assess potential confounding created by missing data. The effect of the frequency of condom use was evaluated by multivariate analysis with the inclusion of other variables that were found to be significant (P<0.10) in univariate analyses. Similar analyses were performed to evaluate risk factors for high-risk types of HPV (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 73, and 82), 20,21 low-risk types (6, 11, 40, 42, 54, 55, 57, 61, 62, 64, 69, 70, 71, 72, 81, 83, 84, and CP6108), 20,21 and types 6, 11, 16, and 18 (which are included in quadrivalent vaccine trials 22 ). To evaluate whether the effect of condom use on the risk of HPV infection differed according to the location in the genital tract, similar analyses were performed to examine risk factors for incident cervical and vulvovaginal infections.
For the subanalyses, sufferers whose people utilized condoms 100 percent of the time was basically put into one or two kinds on the basis of the solutions to help you the question “Did the lover’s manhood ever before reach the hole of one’s snatch without good condom?” In the event the subjects usually responded “no” for each work out of vaginal intercourse when you look at the seven-month several months, they were coded given that having got “no vaginal contact in place of an effective condom.” Analyses have been did since the demonstrated more than, which have four categories of new frequency of condom fool around with (100 % without having any genital contact without an excellent condom, completely with otherwise a not known frequency out of genital get in touch with instead a good condom, and you may about three organizations less than 100 percent, since described over).
Likewise, Cox proportional-risks models were utilized to determine exposure items to the detection regarding event cervical squamous intraepithelial lesions when you look at the 7 months in advance of confirmed Pap take to (on the basis of a previous observance that the majority of sores are present appropriate event disease 23 ). Good 51-time lag before each visit are provided once the 51 months was brand new shortest observed interval between your date a lady basic got sex and also the go out of detection from an instance lesion in the this study. Data getting such as subjects had been censored after the earliest recognition out-of an instance lesion.
Results
The brand new suggest (±SD) period of brand new 82 victims at subscription is 19.3±0.seven ages. The new sufferers accomplished 709 visits. The fresh new suggest pursue-up date is 33.9±11.8 months, the new mean number of check outs for every woman are 8.6±2.nine, as well as the median time between visits are 4.step one weeks. Diary study were ninety.eight per cent done, and you will condom investigation was basically recorded to your 99.step 3 per cent from days one to sex try claimed.
Desk dos
This new twelve-day collective frequency from a first HPV infection shortly after earliest gender was 37.2 per cent (95 percent depend on interval, twenty seven.dos to forty two.cuatro per cent). A total of 126 experience sort of-specific Video dating apps reddit bacterial infections was indeed recognized within the 40 people when they basic got sex ( Dining table dos ). Incident infections were understood inside the three ladies prior to it stated having intercourse for the first time, and additionally you to positive for HPV particular 51, one to for HPV style of 6, and one to have HPV types forty, 61, and you can 66. Brand new twenty-four-times collective occurrence of cervical squamous intraepithelial sores is actually 15.0 per cent (95 percent believe interval, 8.step three to twenty-six.2 %).
